Journal
NEUROLOGY
Volume 90, Issue 22, Pages E1979-E1988Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000005607
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Funding
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante, Mutuelle Generale de l'Education Nationale
- Institut de la Longevite
- regional government of Aquitaine
- regional government of Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- French National Research Agency COGINUT [ANR-06-PNRA-005]
- Fondation Plan Alzheimer (FCS)
- Caisse Nationale pour la Solidarite et l'Autonomie
- INSERM [F-33750]
- Activ'Inside (Beychac et Caillau, France) [F-33750]
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Objective To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. Methods We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. Results The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend < 0.01) in multivariate models. Conclusions In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.
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