Journal
NEUROLOGICAL RESEARCH
Volume 40, Issue 3, Pages 231-238Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/01616412.2018.1428390
Keywords
Electrical stimulation; injured facial nerve; regeneration and re-myelination of axons; facial paralysis scores
Categories
Funding
- Foundation for Military Medicine, China [BWS11C035]
- Shanghai Municipal Science and Technology Commission [14DZ1940103, 14411960400]
- Shanghai Municipal Commission of Health and Family Planning [2014ZYJB0005]
- Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai [PWZxq2017-04]
Ask authors/readers for more resources
Objective: To investigate the effects of electrical stimulation (ES) on the nerve regeneration and functional recovery of facial expression muscles in facial nerve defect rats. Methods: Sixty rats were surgically introduced with a 1-cm defect on the right facial nerves and evenly divided into the Surgery group (Group A, the main trunk of the right facial nerve was surgically cut-off with a 1.0 cm at the foramina stylomastoideum) and the Surgery + ES group (Group B). Twenty normal rats were as normal control group (without receiving surgery or ES). For rats in group B, the orbicularis oris muscle of the right paralyzed face was stimulated with an electrical pulse of 3 V, 20 Hz and 0.3 mA for 1 h each day. The effects of ES on the facial muscle movement, compound muscle action potentials (CMAPs), histological structure, and the expression levels of S100B and NF200 proteins were comparatively studied. Results: In group A, facial paralysis scores were slightly improved from day 1 to 28; the facial nerve trunks had swelled and malformed till day 14; and CMAPs could be induced in fewer animals and were abnormal, resulting in a slow recovery of the facial muscle movement. In group B, facial paralysis scores were improved from 4 to 2.6 during the 4 weeks; more rats showed a higher amplitude and shorter latency of CMAPs from day 14 to 28 after surgery; and increased axons and the expression of S100B and NF200 proteins and gradually decreased swelling in the injured facial nerve. Conclusion: ES promotes outgrowth and myelination of axons and a partial functional recovery of facial muscles in injured facial nerve rats.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available