Journal
NEUROIMAGE
Volume 166, Issue -, Pages 400-424Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2017.10.034
Keywords
Epidemiological studies; Image analysis pipeline; Multi-modal data integration; Quality control; Big data imaging; Machine learning
Funding
- UK Medical Research Council
- Wellcome Trust
- NIHR Oxford Biomedical Research Centre
- Monument Trust Discovery Award from Parkinson's UK
- UK Medical Research Council (MRC) [MR/K006673/1]
- Engineering and Physical Sciences Research Council [D4TD4D12/HM12.01]
- Wellcome Trust UK Strategic Award [098369/Z/12/Z]
- Wellcome Trust [203139/Z/16/Z]
- Engineering and Physical Sciences Research Council [EP/M029778/1, EP/N014529/1, EP/N018702/1, EP/L023067/1, EP/L022680/1, EP/M020533/1, EP/J005444/1, EP/G007748/1, EP/I027084/1, EP/M00855X/1] Funding Source: researchfish
- International Spinal Research Trust [IMG006] Funding Source: researchfish
- Medical Research Council [MR/K02213X/1, MR/L009013/1, MC_qA137853, MR/M024903/1, MC_PC_17114, MR/K006673/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0514-10022] Funding Source: researchfish
- EPSRC [EP/L022680/1, EP/L023067/1, EP/M00855X/1, EP/G007748/1, EP/N014529/1, EP/M029778/1, EP/I027084/1, EP/M020533/1, EP/N018702/1, EP/J005444/1] Funding Source: UKRI
- MRC [MC_PC_17114, MR/K02213X/1, MR/L009013/1, MR/K006673/1, MR/M024903/1] Funding Source: UKRI
Ask authors/readers for more resources
UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound and low-dose bone/fat x-ray. The brain imaging component covers 6 modalities (T1, T2 FLAIR, susceptibility weighted MRI, Resting fMRI, Task fMRI and Diffusion MRI). Raw and processed data from the first 10,000 imaged subjects has recently been released for general research access. To help convert this data into useful summary information we have developed an automated processing and QC (Quality Control) pipeline that is available for use by other researchers. In this paper we describe the pipeline in detail, following a brief overview of UK Biobank brain imaging and the acquisition protocol. We also describe several quantitative investigations carried out as part of the development of both the imaging protocol and the processing pipeline.
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