Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 114, Issue -, Pages 127-133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2018.02.003
Keywords
Cholinergic transmission; Ventral tegmental area; Pedunculopontine tegmental nucleus; Laterodorsal tegmental nucleus; Structure; Function
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Funding
- Key Laboratory Fund of Philosophy and Social Sciences of Universities in Guangdong Province (Psychological Assessment and Rehabilitation for Exceptional Children)
- Postdoctoral Foundation of Jiangsu Province [1601180B]
- China Postdoctoral Science Foundation Funded Project [2016M601841]
- China Postdoctoral Science Foundation Specially Funded Project [2017T100382]
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The ventral tegmental area (VTA), a pivotal brain region of the mesocorticolimbic dopaminergic system, is substantially innervated and modulated by cholinergic projections from the pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus. In this review, we focus mainly on the current findings on VTA cholinergic compositions and functions, including VTA cholinergic innervations and synaptic connectivity, acetylcholine receptor expression and functional characteristics, cholinergic modulation of neuronal activity and dopamine efflux, cholinergic modulation of VTA-mediated behaviors such as reward and addiction, stress and depression, locomotion, etc. Taken together, these findings indicate that cholinergic transmission to the VTA plays an important role in modulation of the VTA circuit, which is implicated in regulation of multiple behaviors. (C) 2018 Elsevier Ltd. All rights reserved.
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