Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 151, Issue -, Pages 28-34Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2018.03.021
Keywords
Wheel running; Fear conditioning; Fear renewal; Dopamine; Voluntary exercise; Exposure therapy
Funding
- National Institutes of Health [R15 MH114026]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R15MH114026] Funding Source: NIH RePORTER
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Extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear tends to resurface even after successful extinction. Identification of novel strategies to enhance fear extinction and reduce fear relapse is of paramount importance to mental health. Exercise can enhance cognitive function, but it is not yet well understood whether exercise can be an effective augmentation strategy for fear extinction. In the current review, we present the current state of knowledge on the effects of exercise on fear extinction. Effects of exercise duration, explanations for conflicting results, and potential mechanisms, focusing on a hypothesized role for dopamine, are all discussed. We also provide new data suggesting that the timing in which acute exercise occurs relative to fear extinction, is a crucial variable in determining whether exercise can enhance fear extinction. Clinical implications and ideas to guide future research endeavors in this area are provided.
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