Journal
NEURO-ONCOLOGY
Volume 20, Issue 7, Pages 873-884Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noy020
Keywords
characterization; evolution; glioma; sequencing; subtypes
Categories
Funding
- National Brain Tumor Society
- Oligo Research Fund
- Austrian Science Fund [KLI394]
- Austrian Academy of Science
- European Research Council (European Union Horizon 2020 Research and Innovation Program) [679146]
- Televie grant
- Dutch Cancer Society KWF Grant [11026]
- Cancer Prevention and Research Institute of Texas Grant [R140606]
- NIH-NCI [P30-CA138292]
- Henry Ford Hospital institutional grant
- Sao Paulo Research Foundation (FAPESP) [2015/07925-5, 2016/15485-8, 2014/08321-3]
- Leeds Teaching Hospitals Charitable Foundation [9R11/14-11]
- Else Kroner-Fresenius-Stiftung [2015_Kolleg_14]
- NHMRC Program [1037786]
- Cancer Australia
- Austrian Science Fund (FWF) [KLI394] Funding Source: Austrian Science Fund (FWF)
- MRC [G1100578, G0701018, MR/N004272/1] Funding Source: UKRI
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Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.
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