Journal
NATURE REVIEWS IMMUNOLOGY
Volume 13, Issue 9, Pages 649-665Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri3499
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Funding
- Canadian Institutes of Health Research (CIHR)
- Canadian Breast Cancer Foundation (CBCF)
- Canadian Cancer Society Research Institute (CCSRI)
- Heart & Stroke Foundation of Canada
- Ontario Institute of Cancer Research (OICR)
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Over the past 50 years, steady growth in the field of metalloproteinase biology has shown that the degradation of extracellular matrix components represents only a fraction of the functions performed by these enzymes and has highlighted their fundamental roles in immunity. Metalloproteinases regulate aspects of immune cell development, effector function, migration and ligand-receptor interactions. They carry out ectodomain shedding of cytokines and their cognate receptors. Together with their endogenous inhibitors TIMPs (tissue inhibitor of metalloproteinases), these enzymes regulate signalling downstream of the tumour necrosis factor receptor and the interleukin-6 receptor, as well as that downstream of the epidermal growth factor receptor and Notch, which are all pertinent for inflammatory responses. This Review discusses the metalloproteinase family as a crucial component in immune cell development and function.
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