Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 25, Issue 1, Pages 4-12Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41594-017-0011-7
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Funding
- National Institutes of Health [R01NS028471, R01GM083118]
- German Academic Exchange Service (DAAD)
- American Heart Association [17POST33410958]
- Chan Zuckerberg Biohub
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM083118] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS028471] Funding Source: NIH RePORTER
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G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering intracellular signaling through coupling with G proteins and arrestins. Recent breakthroughs in the structural determination of GPCRs and GPCR-transducer complexes represent important steps toward deciphering GPCR signal transduction at a molecular level. A full understanding of the molecular basis of GPCR-mediated signaling requires elucidation of the dynamics of receptors and their transducer complexes as well as their energy landscapes and conformational transition rates. Here, we summarize current insights into the structural plasticity of GPCR-G-protein and GPCR-arrestin complexes that underlies the regulation of the receptor's intracellular signaling profile.
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