Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 19, Issue 6, Pages 349-364Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0003-4
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Funding
- Deutsche Forschungsgemeinschaft [SFB 1177]
- European Research Council (ERC) advanced grant [742720]
- LOEWE program Ubiquitin Networks (Ub-Net)
- LOEWE Center for Gene and Cell Therapy Frankfurt (CGT)
- Israeli Science Foundation [1247/15]
- Legacy Heritage Fund [1935/16]
- Minerva foundation
- Federal German Ministry for Education and Research
- European Research Council (ERC) [742720] Funding Source: European Research Council (ERC)
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Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the event of energy or nutrient shortage and responds to various cytotoxic insults. Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimuli that cells experience, thereby conferring adaptation to the ever-changing environment. It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
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