Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 19, Issue 9, Pages 563-578Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0029-7
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Funding
- National Institute of Neurological Disorders and Stroke [R01 NS089754]
- NCI [2R01 CA109035, R01CA204996]
- US National Institutes of Health (NIH) National Cancer Institute (NCI) [P30CA016672, 2P50 CA127001]
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Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly - through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators. Deregulation of these metabolic activities has been implicated in human diseases, prominently including cancer.
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