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Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non-Small Cell Lung Cancer
Jim Sang et al.
CANCER DISCOVERY (2013)
Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Esra A. Akbay et al.
CANCER DISCOVERY (2013)
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance
Eva Maria Putz et al.
CELL REPORTS (2013)
Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans
Erica K. Evans et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Lectin Microarray Profiling and Relative Quantification of Glycome Associated With Proteins of Neonatal wt and rd1 Mice Retinae
Satpal Ahuja
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
Dysregulation of the basal RNA polymerase transcription apparatus in cancer
Megan J. Bywater et al.
NATURE REVIEWS CANCER (2013)
c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
Zuqin Nie et al.
CELL (2012)
Chemistry-based functional proteomics for drug target deconvolution
Kui Wang et al.
EXPERT REVIEW OF PROTEOMICS (2012)
Plasmodium kinases as targets for new-generation antimalarials
Isabelle S. Lucet et al.
FUTURE MEDICINAL CHEMISTRY (2012)
Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors
Xingyu Lin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Jeffrey M. Axten et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Iana M. Serafimova et al.
NATURE CHEMICAL BIOLOGY (2012)
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair
Xue Zhang et al.
NATURE GENETICS (2012)
AXL and acquired resistance to EGFR inhibitors
Sophie Postel-Vinay et al.
NATURE GENETICS (2012)
Drug repositioning for Alzheimer's disease
Anne Corbett et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Ranibizumab Combined With Low-Dose Sorafenib for Exudative Age-Related Macular Degeneration
Teresa Diago et al.
MAYO CLINIC PROCEEDINGS (2012)
Mechanisms of Age-Related Macular Degeneration
Jayakrishna Ambati et al.
NEURON (2012)
Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis
Roy Fleischmann et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer
Julie R. Brahmer et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Conjugate Adaptation of Smooth Pursuit during Monocular Viewing in Strabismic Monkeys with Exotropia
Seiji Ono et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2012)
Combining immunotherapy and targeted therapies in cancer treatment
Matthew Vanneman et al.
NATURE REVIEWS CANCER (2012)
Redox-Based Probes for Protein Tyrosine Phosphatases
Stephen E. Leonard et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Receptor Tyrosine Kinases and Targeted Cancer Therapeutics
Kenji Takeuchi et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Receptor Tyrosine Kinases and TLR/IL1 Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
Michael C. Schmid et al.
CANCER CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases
Matthew P. Patricelli et al.
CHEMISTRY & BIOLOGY (2011)
High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors
Chandrasekhar V. Miduturu et al.
CHEMISTRY & BIOLOGY (2011)
New Frontiers in Chemical Biology: Enabling Drug Discovery. Edited by Mark E. Bunnage.
Joshua Kritzer
ChemMedChem (2011)
Signaling cell death from the endoplasmic reticulum stress response
Gordon C. Shore et al.
CURRENT OPINION IN CELL BIOLOGY (2011)
Mechanisms of drug resistance in kinases
Rina Barouch-Bentov et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)
Role of LRRK2 kinase dysfunction in Parkinson disease
Azad Kumar et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)
Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment
Jayme B. Stokes et al.
MOLECULAR CANCER THERAPEUTICS (2011)
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ε and Wnt/β-catenin independent inhibition of mitotic spindle formation
J. K. Cheong et al.
ONCOGENE (2011)
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
Ryohei Katayama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species
Revati Wani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1
Xianming Deng et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene
Zhao Chen et al.
CANCER RESEARCH (2010)
Understanding Kinase Selectivity Through Energetic Analysis of Binding Site Waters
Daniel D. Robinson et al.
CHEMMEDCHEM (2010)
The (un)targeted cancer kinome
Oleg Fedorov et al.
NATURE CHEMICAL BIOLOGY (2010)
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis.
Michael E. Weinblatt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Vinyl sulfone: a versatile function for simple bioconjugation and immobilization
Julia Morales-Sanfrutos et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2010)
Activity-based protein profiling for biochemical pathway discovery in cancer
Daniel K. Nomura et al.
NATURE REVIEWS CANCER (2010)
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
Elisa Greggio et al.
ASN NEURO (2009)
Neutralization of Vascular Endothelial Growth Factor Antiangiogenic Isoforms Is More Effective Than Treatment with Proangiogenic Isoforms in Stimulating Vascular Development and Follicle Progression in the Perinatal Rat Ovary
Robin A. Artac et al.
BIOLOGY OF REPRODUCTION (2009)
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
Dan Han et al.
CELL (2009)
Targeting protein kinases for the development of anti-inflammatory drugs
Philip Cohen
CURRENT OPINION IN CELL BIOLOGY (2009)
Protein kinases as antibacterial targets
Mark Schreiber et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang et al.
NATURE REVIEWS CANCER (2009)
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
Frances Rena Bahjat et al.
ARTHRITIS AND RHEUMATISM (2008)
Role of the active-site solvent in the thermodynamics of factor Xa ligand binding
Robert Abel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
High-throughput kinase profiling as a platform for drug discovery
David M. Goldstein et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Immunobiology of the TAM receptors
Greg Lemke et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff et al.
NATURE BIOTECHNOLOGY (2007)
Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells
Heather M. Seitz et al.
JOURNAL OF IMMUNOLOGY (2007)
Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding
Tom Young et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Christian Rommel et al.
NATURE REVIEWS IMMUNOLOGY (2007)
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
Jiahai Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases
Anouk Caraux et al.
NATURE IMMUNOLOGY (2006)
Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis
D Borgel et al.
CRITICAL CARE MEDICINE (2006)
Toll-Like Receptor (TLR) Response Tolerance: A Key Physiological Damage Limitation Effect and an Important Potential Opportunity for Therapy
Andrea Broad et al.
CURRENT MEDICINAL CHEMISTRY (2006)
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
JJ Credle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
GQ Phan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Thermodynamic contributions of the ordered water molecule in HIV-1 protease
Z Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Protein kinase inhibitors as a therapeutic modality
A Levitzki
ACCOUNTS OF CHEMICAL RESEARCH (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding et al.
MOLECULAR CELL (2003)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
NATURE (2002)
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae
SB Ficarro et al.
NATURE BIOTECHNOLOGY (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
The regulation of protein function by multisite phosphorylation - a 25 year update
P Cohen
TRENDS IN BIOCHEMICAL SCIENCES (2000)