Journal
NATURE REVIEWS CLINICAL ONCOLOGY
Volume 15, Issue 7, Pages 459-466Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41571-018-0004-4
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Funding
- Maag Lever Darm Stichting (MLDS) [FP13-15]
- Universiteitsfonds Limburg/SWOL
- SU2C-DCS International Translational Cancer Research Dream Team Grant (Stand Up To Cancer (SU2C)) [AACR-DT1415]
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Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than 14,000 scientific publications describing DNA methylation-based biomarkers and their clinical associations in cancer, only 14 of these biomarkers have been translated into a commercially available clinical test. Methodological and experimental obstacles are both major causes of this disparity, but the genomic location of a DNA methylation-based biomarker is an intrinsic and essential property that also has an important and often overlooked role. Here, we examine the importance of the location of DNA methylation for the development of cancer biomarkers, and take a detailed look at the genomic location and other relevant characteristics of the various biomarkers with commercially available tests. We also emphasize the value of publicly available databases for the development of DNA methylation-based biomarkers and the importance of accurate reporting of the full methodological details of research findings.
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