Journal
NATURE NEUROSCIENCE
Volume 21, Issue 3, Pages 404-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41593-018-0071-y
Keywords
-
Categories
Funding
- Boston College Undergraduate Research Fellowships
- National Science Foundation [1258923]
- NIH [MH103401, MH093412, MH109545]
- Brain and Behavior Research Foundation [19417]
- Direct For Education and Human Resources
- Division Of Graduate Education [1258923] Funding Source: National Science Foundation
Ask authors/readers for more resources
Social animals detect the affective states of conspecifics and utilize this information to orchestrate social interactions. In a social affective preference text in which experimental adult male rats could interact with either naive or stressed conspecifics, the experimental rats either approached or avoided the stressed conspecific, depending upon the age of the conspecific. Specifically, experimental rats approached stressed juveniles but avoided stressed adults. Inhibition of insular cortex, which is implicated in social cognition, and blockade of insular oxytocin receptors disrupted the social affective behaviors. Oxytocin application increased intrinsic excitability and synaptic efficacy in acute insular cortex slices, and insular oxytocin administration recapitulated the behaviors observed toward stressed conspecifics. Network analysis of c-Fos immunoreactivity in 29 regions identified functional connectivity between insular cortex, prefrontal cortex, amygdala and the social decision-making network. These results implicate insular cortex as a key component in the circuit underlying age-dependent social responses to stressed conspecifics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available