Journal
NATURE NEUROSCIENCE
Volume 21, Issue 6, Pages 799-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-018-0156-7
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Funding
- NIMH [096816, 112356]
- NINDS [076708]
- Department of Defense [AR120254]
- Sammons Enterprises
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The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD).Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD.
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