Journal
NATURE METHODS
Volume 15, Issue 7, Pages 531-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0036-9
Keywords
-
Categories
Funding
- NIH TCGA Genome Data Analysis Center [U24CA143845]
- MGH Cancer Center
- National Human Genome Research Institute, NIH [T32 HG002295]
- NIH [NCI P01CA206978-01, R01CA182461-01, U10CA180861-01, R01CA184922-02]
Ask authors/readers for more resources
Comparison of sequencing data from a tumor sample with data from a matched germline control is a key step for accurate detection of somatic mutations. Detection sensitivity for somatic variants is greatly reduced when the matched normal sample is contaminated with tumor cells. To overcome this limitation, we developed deTiN, a method that estimates the tumor-in-normal (TiN) contamination level and, in cases affected by contamination, improves sensitivity by reclassifying initially discarded variants as somatic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available