Journal
NATURE METHODS
Volume 15, Issue 4, Pages 267-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.4628
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Single-cell RNA sequencing and high-dimensional cytometry can be used to generate detailed trajectories of dynamic biological processes such as differentiation or development. Here we present cellAlign, a quantitative framework for comparing expression dynamics within and between single-cell trajectories. By applying cellAlign to mouse and human embryonic developmental trajectories, we systematically delineate differences in the temporal regulation of gene expression programs that would otherwise be masked.
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