Journal
NATURE METHODS
Volume 15, Issue 6, Pages 437-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0007-1
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Funding
- NCI CPTAC PCC [1U24CA210986-01]
- Broad Institute (SPARC grant)
- Pediatric Scientist Development Program
- March of Dimes Birth Defects Foundation
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Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts.
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