Journal
NATURE MEDICINE
Volume 24, Issue 4, Pages 484-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4502
Keywords
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Funding
- Veterans Administration (Gordon Mansfield Spinal Cord Injury Collaborative Consortium) [RRD B7332R, RRD RX001045]
- National Institutes of Health [R01 NS042291, R01 NS104442]
- Department of Defense [W81XWH-12-1-0592]
- Craig H. Neilsen Foundation
- Bernard and Anne Spitzer Charitable Trust
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
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We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.
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