Journal
NATURE IMMUNOLOGY
Volume 19, Issue 7, Pages 659-664Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-018-0128-9
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Funding
- US National Institutes of Health
- Helmsley Charitable Trust
- California Institute of Regenerative Medicine
- Larry L. Hillblom Foundation
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Although the thymus has long been recognized as a key organ for T cell selection, the intricate details linking these selection events to human autoimmunity have been challenging to decipher. Over the last two decades, there has been rapid progress in understanding the role of thymic tolerance mechanisms in autoimmunity through genetics. Here we review some of the recent progress in understanding key thymic tolerance processes that are critical for preventing autoimmune disease.
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