Journal
NATURE IMMUNOLOGY
Volume 19, Issue 2, Pages 173-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-017-0029-3
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Funding
- Howard Hughes Medical Institute Faculty Scholars program
- US National Institutes of Health [R01AI111671, R01AI084913, R21AI123600]
- US National Institute of Allergy and Infectious Diseases
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007313, ZIAAI001225, R01AI084913, R21AI123600, R01AI111671] Funding Source: NIH RePORTER
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CD8(+) T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Here we used two-photon intravital microscopy to visualize the responses of CD8(+) resident memory T cells (T-RM cells) within the reproductive tracts of live female mice. We found that mucosal T-RM cells were highly motile, but paused and underwent in situ division after local antigen challenge. T-RM cell reactivation triggered the recruitment of recirculating memory T cells that underwent antigen-independent T-RM cell differentiation in situ. However, the proliferation of pre-existing T-RM cells dominated the local mucosal recall response and contributed most substantially to the boosted secondary T-RM cell population. We observed similar results in skin. Thus, T-RM cells can autonomously regulate the expansion of local immunosurveillance independently of central memory or proliferation in lymphoid tissue.
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