Journal
NATURE GENETICS
Volume 50, Issue 5, Pages 652-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41588-018-0100-5
Keywords
-
Categories
Funding
- Medical Research Council program grant [MC_UU_12013/4]
- UK Medical Research Council
- Wellcome Trust [092731, 102215/2/13/2, 105022/Z/14/Z]
- University of Bristol
- Australian Research Council Future Fellowship [FT130101709]
- Netherlands Organization for Scientific Research (NWO) [91203014]
- Center of Medical Systems Biology (CMSB)
- Hersenstichting Nederland
- Internationale Stichting Alzheimer Onderzoek (ISAO)
- Alzheimer Association [04516]
- Hersenstichting Nederland [12F04(2).76]
- Interuniversity Attraction Poles (IUAP) program
- European Commission FP6 STRP [018947 (LSHG-CT-2006-01947)]
- European Community's Seventh Framework Programme (FP7) by the European Commission under the program Quality of Life and Management of the Living Resources of 5th Framework Programme [HEALTH-F4-2007-201413, QLG2-CT-2002-01254]
- Netherlands Organization for Scientific Research
- Russian Foundation for Basic Research [NWO-RFBR 047.017.043]
- Compagnia di San Paolo, Torino, Italy
- Fondazione Cariplo, Italy
- Ministry of Health
- Ricerca Finalizzata
- CCM
- Telethon, Italy
- Italian Ministry of Health (RF)
- FVG Region
- Fondo Trieste
- Netherlands Organization for Scientific Research [NWO: 016-115-035, 463-06-001, 451-04-034]
- ZonMW [31160008, 911-09-032]
- Institute for Health and Care Research (EMGO+)
- Biomolecular Resources Research Infrastructure (BBMRI-NL) [184.021.007]
- European Research Council [ERC-230374]
- NWO/SPI [56-464-14192]
- Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health
- Rutgers University Cell and DNA Repository [NIMH U24 MH068457-06]
- Avera Institute
- Sioux Falls (USA)
- National Institutes of Health [NIH R01 HD042157-01A1, MH081802, 1RC2 MH089951, 1RC2 MH089995]
- China Scholarship Council [201206180099]
- Australian National Health and Medical Research Council [241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498]
- Australian Research Council [A7960034, A79906588, A79801419, DP0770096, DP0212016, DP0343921]
- FP-5 GenomEUtwin Project [QLG2-CT-2002-01254]
- US National Institutes of Health (NIH) [AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206]
- Netherlands Scientific Organization [NWO 480-05-003]
- National Health and Medical Research Council (NHMRC) Fellowship Scheme
- Australian National Health and Medical Research Council (NHMRC) project [1021105]
- Lions Eye Institute
- Australian Foundation for the Prevention of Blindness
- Ophthalmic Research Institute of Australia
- NHMRC Early Career Fellowship (CJ Martin - Overseas Biomedical Fellowship)
- Netherlands Organization of Scientific Research NWO Investments [175.010.2005.011, 911-03-012]
- Research Institute for Diseases in the Elderly [014-93-015, RIDE2]
- Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO) [050-060-810]
- Erasmus MC and Erasmus University Rotterdam
- Netherlands Organization for Scientific Research (NWO)
- Netherlands Organization for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE) the Netherlands Genomics Initiative (NGI)
- Ministry of Education, Culture and Science
- Ministry of Health Welfare and Sport
- European Commission (DG XII)
- Municipality of Rotterdam
- Chinese recruiting program
- National Thousand Young Talents Award
- National Natural Science Foundation of China (NSFC) [91651507]
- European Community's Seventh Framework Programme (FP7)
- National Institute for Health Research (NIHR)
- MRC [MC_UU_12013/4] Funding Source: UKRI
- Wellcome Trust [105022/Z/14/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but 13 are novel. Collectively, single-nucleotide polymorphisms associated with hair color within these loci explain 34.6% of red hair, 24.8% of blond hair, and 26.1% of black hair heritability in the study populations. These results confirm the polygenic nature of complex phenotypes and improve our understanding of melanin pigment metabolism in humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available