Journal
NATURE GENETICS
Volume 50, Issue 6, Pages 857-+Publisher
NATURE RESEARCH
DOI: 10.1038/s41588-018-0121-0
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Funding
- National Heart, Lung, and Blood Institute (NHLBI) [R01HL060710, R56HL134356, R01HL114769, AAF15-0097, R00MH101367]
- National Institutes of Health
- American Asthma Foundation
- National Institute of Mental Health
- MRC [MC_PC_12028] Funding Source: UKRI
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R56HL134356, R01HL060710, R01HL114769] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R00MH101367] Funding Source: NIH RePORTER
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Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg = 0.75, P = 6.84 x 10(-62)). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci. Computational analysis showed that shared genetic loci are enriched in immune/inflammatory systems and tissues with epithelium cells. Our work identifies common genetic architectures shared between asthma and allergy and will help to advance understanding of the molecular mechanisms underlying co-morbid asthma and allergic diseases.
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