Journal
NATURE CHEMICAL BIOLOGY
Volume 14, Issue 8, Pages 821-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0091-7
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Funding
- National Science Foundation [1553649, 1227034]
- Office of Naval Research [N000141612525]
- American Heart Association [12SDG12090025]
- Center for Advanced Study at UIUC
- National Center for Supercomputing Applications
- Paul G. Allen Frontiers Group
- Defense Threat Reduction Agency [HDTRA1-14-1-0006]
- U.S. Department of Defense (DOD) [N000141612525] Funding Source: U.S. Department of Defense (DOD)
- Directorate For Engineering
- Div Of Engineering Education and Centers [1227034] Funding Source: National Science Foundation
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Designer microbial consortia are an emerging frontier in synthetic biology that enable versatile microbiome engineering. However, the utilization of such consortia is hindered by our limited capacity in rapidly creating ecosystems with desired dynamics. Here we present the development of synthetic communities through social interaction engineering that combines modular pathway reconfiguration with model creation. Specifically, we created six two-strain consortia, each possessing a unique mode of interaction, including commensalism, amensalism, neutralism, cooperation, competition and predation. These consortia follow distinct population dynamics with characteristics determined by the underlying interaction modes. We showed that models derived from two-strain consortia can be used to design three- and four-strain ecosystems with predictable behaviors and further extended to provide insights into community dynamics in space. This work sheds light on the organization of interacting microbial species and provides a systematic framework-social interaction programming-to guide the development of synthetic ecosystems for diverse purposes.
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