Journal
NATURE CHEMICAL BIOLOGY
Volume 14, Issue 9, Pages 837-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0097-1
Keywords
-
Categories
Funding
- National Institutes of Health (NIH) [R37 GM086868, R01 GM107047, P01 CA196539]
- NIH [1F32GM110880, 5F32CA206418]
Ask authors/readers for more resources
Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
