Journal
NATURE CHEMICAL BIOLOGY
Volume 14, Issue 7, Pages 652-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0068-6
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- Deutsche Forschungsgemeinschaft [SU 239/25-1]
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The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.
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