Journal
NATURE CELL BIOLOGY
Volume 20, Issue 4, Pages 373-381Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0038-y
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Funding
- National Institutes of Health [R01 HL082792, U54 CA210184]
- Department of Defense Breast Cancer Research Program [BC150580]
- National Science Foundation (CAREER Award) [CBET-1254846, MCB-1715606]
- Fleming Postdoctoral Fellowship
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The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. Here we discuss recent findings that support a direct role of the nucleus in cellular mechanosensing and highlight novel tools to study nuclear mechanotransduction.
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