Journal
NATURE CELL BIOLOGY
Volume 20, Issue 3, Pages 233-242Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41556-018-0037-z
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Funding
- NIH [GM053396]
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Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past three decades, selective autophagy has been characterized as a highly regulated and specific degradation pathway for removal of unwanted cytosolic components and damaged and/or superfluous organelles. Here, we discuss different types of selective autophagy, emphasizing the role of ligand receptors and scaffold proteins in providing cargo specificity, and highlight unanswered questions in the field.
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