4.8 Article

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Journal

NATURE CELL BIOLOGY
Volume 20, Issue 7, Pages 800-+

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0130-3

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Funding

  1. Dutch Cancer Society
  2. Netherlands Organisation for Scientific Research (NWO) (VICI grant) [865.12.004]
  3. Dutch Cancer Society [KWF/HUBR-11080]
  4. ERC [675737]
  5. Proteins@Work initiative of the Netherlands Proteomics Centre
  6. Horizon 2020 iNEXT project [653706]

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Faithful chromosome segregation depends on the ability of sister kinetochores to attach to spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to form a fibrous corona, and compacts following microtubule capture. Here we show that the dynein adaptor Spindly and the RZZ (ROD-Zwilch-ZW10) complex drive kinetochore expansion in a dynein-independent manner. C-terminal farnesylation and MPS1 kinase activity cause conformational changes of Spindly that promote oligomerization of RZZ-Spindly complexes into a filamentous meshwork in cells and in vitro. Concurrent with kinetochore expansion, Spindly potentiates kinetochore compaction by recruiting dynein via three conserved short linear motifs. Expanded kinetochores unable to compact engage in extensive, long-lived lateral microtubule interactions that persist to metaphase, and result in merotelic attachments and chromosome segregation errors in anaphase. Thus, dynamic kinetochore size regulation in mitosis is coordinated by a single, Spindly-based mechanism that promotes initial microtubule capture and subsequent correct maturation of attachments.

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