Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 9, Pages 1340-1344Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1475385
Keywords
Marine sponge; Dactylospongia elegans; steroids; cytotoxicity; X-ray crystal analysis
Categories
Funding
- National Natural Science Fund of China [U1605221, 41376155, 21672084, 41476121, 41576130, 81741151]
- Guangzhou Science and Technology Project [201704030042]
Ask authors/readers for more resources
A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5 alpha,8 alpha-epidioxy-cholest-6-en-3 beta-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC50 values of 9.7 and 8.5 mu M, respectively. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available