Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 8, Pages 1191-1195Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1465423
Keywords
Marine-derived fungi; Aspergillus versicolor; epigenetic manipulation; antibacterial activity
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Funding
- National Natural Science Foundation of China [41776168, 41706167]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201737271]
- Projects for Common Wealth [2015C10026, 2017C10016]
- National 111 Project of China [D16013]
- Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
- K.C. Wong Magna Fund in Ningbo University
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Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 mu g/mL. [GRAPHICS] .
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