Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 23, Pages 3404-3408Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1480622
Keywords
Marine-derived fungi; Aspergillus versicolor; furandione; antifungal activity
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Funding
- National Natural Science Foundation of China [41776168, 41706167, 21672084, 41376155, 81302665]
- Projects for Common Wealth [2017C10016]
- Science and Technology Planning Project of Guangzhou [201710010088, 201704030042]
- Scientific Research Cultivation and Innovation Fund Research Project of Jinan University [21616113, 21617472]
- National 111 Project of China [D16013]
- Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
- K.C. Wong Magna Fund in Ningbo University
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Two new furandione derivatives, designated as asperfurandiones A (1) and B (2), were isolated from the solid culture of the marine-derived fungus Aspergillus versicolor. Their structures were elucidated using a combination of mass spectrometry and NMR spectroscopy. Additionally, asperfurandiones A and B both showed moderate antifungal activity against Gaeumannomyces graminis, Cryptococcus neoformans, and Candida albicans with MIC values of 64??g/mL.
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