Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 24, Pages 3577-3581Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1483927
Keywords
Curcumin; genistein; rhodesain; drug combination studies; synergism
Categories
Funding
- University of Messina
Ask authors/readers for more resources
Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is?
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available