Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 9, Pages 1304-1309Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1472597
Keywords
Endophytic fungus; Xylaria sp; sesquiterpene; antibacterial activity
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Funding
- National Natural Science Foundation of China [21762007]
- Guangxi Natural Science Foundation of China [2014GXNSFAA118055]
- Project of State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2015-A03, CMEMR2016-A06]
- Guangxi Highland Medical and Pharmaceutical Industries Talents Foundation [1310]
- Science Research and Technology Development Program of Guilin, China [2016010301-2]
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A new eremophilane sesquiterpene, xylareremophil (1), together with five known eremophilanes, 1 alpha,10 alpha-epoxy-3 alpha-hydroxyeremophil-7(11)-en-12,8 beta-olide (2), 1,10 alpha,13-trihydroxyeremophil-7(11)-en-12,8-olide (3), 1 alpha,10 alpha-epoxy-13-hydroxyeremophil-7(11)-en-12,8 beta-olide (4), mairetolides B (5) and G (6) were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from Sophora tonkinensis. Their structures were elucidated on the basis of spectroscopic data analysis. The absolute configurations of 1 was determined by comparing computed electronic circular dichroism (ECD) and optical rotation (OR) with experimental results. Compounds 1, 5 and 6 showed antibacterial activities against Proteus vulgaris, Micrococcus luteus, Micrococcus lysodeikticus and Bacillus subtilis with MIC values of 25-100 mu g/mL. [GRAPHICS] .
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