Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 9, Pages 1243-1250Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1466126
Keywords
beta-furanoarabinose; Scutellaria baicalensis; anti-inflammation
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Funding
- Fundamental Research Funds for the Central Universities [106112017CDJXFLX0014, CQDXWL-2014-Z007]
- Special Fund for Basic Scientific Research of Central Colleges, Chongqing University [201310611045]
- Tang Foundations
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Two flavone di-C-glycosides, a pair of isomers, were isolated from Scutellaria baicalensis. The structures of compounds 1 and 2 were elucidated by means of physical data, including 1D and 2D NMR and HR-ESI-MS. Supporting theoretical calculations of the compound conformational landscape has also been conducted for geometry optimization. This is the first report of the natural occurrence of beta-furanoarabinoside. In addition, the effects of compounds 1 and 2 on NO, pro-inflammatory cytokines, PGE2 and COX-2 levels were measured in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. The pair of isomers exhibited significant inhibitory effects on inflammation. [GRAPHICS]
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