Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 23, Pages 3389-3397Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1479702
Keywords
Sorbicillinoids; Trichoderma citrinoviride; marine-derived fungi; anti-inflammatory effect; Cladophora; trichodermanone C; cytotoxicity
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Funding
- MIUR-PON [Linfa 03PE_00026_1, Marea 03PE_00106]
- Regione Puglia [SIX 1410-12/06/2015]
- KENYA-AID [10,306/CEFA/KEN]
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From the green alga Cladophora sp. collected in Italy, the marine fungal strain A12 of Trichoderma citrinoviride was isolated, identified and characterized. LC-MS qTOF analysis was applied to perform a metabolic profile of the fungal culture. Chromatographic techniques and spectroscopic methods were used to isolate and characterize the major secondary metabolites produced by this strain in liquid culture. In particular, four known sorbicillinoids (trichodermanone C, spirosorbicillinol A, vertinolide and sorbicillin) were purified and identified, together with 2-phenylethanol and tyrosol. Moreover, metabolomic analysis allowed to detect small amounts of trichodimerol, rezishanone A, 2?,3?-dihydrosorbicillin and bisvertinol. For the first time a significant inhibitory effect on nitrite levels has been shown for trichodermanone C in lipopolysaccharide-stimulated J774A.1 macrophages.
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