Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 18, Pages 2618-2622Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1462182
Keywords
Sonneratia caseolaris; betulinic acid; alpha-glucosidase inhibition; LPS-stimulated nitric oxide production inhibition
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Funding
- UGC
- Science and Engineering Research Board, New Delhi, India [EMR/2015/002319]
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Chemical manipulation studies were conducted on betulinic acid (1), twenty-one new rationally designed analogues of 1 with modifications at C-28 were synthesized for their evaluation of inhibitory effects on alpha-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. Compound 2 (IC50 = 5.4 mu M) exhibited an almost 1.4-fold increase in alpha-glucosidase inhibitory activity on yeast alpha-glucosidase while analogues 5 (IC50 16.4 mu M) and 11 (IC50 16.6 mu M) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid. [GRAPHICS] .
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