4.7 Review

Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

Journal

NATURAL PRODUCT REPORTS
Volume 35, Issue 7, Pages 633-645

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7np00055c

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI) [JP15H01836, JP16H06443]
  2. JST/NSFC Strategic International Collaborative Research Program
  3. Grants-in-Aid for Scientific Research [16H06443] Funding Source: KAKEN

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Non-heme iron enzymes are a versatile family of oxygenases that catalyze remarkable types of chemistry. This review highlights the intriguing chemistry of non-heme iron enzymes, especially those utilizing alpha-ketoglutarate (alpha-KG) as a co-substrate, in fungal secondary metabolism and aims to summarize how nature diversifies and complexifies natural products.

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