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Bin Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Theoretical and Experimental Studies of the Conversion of Chromopyrrolic Acid to an Antitumor Derivative by Cytochrome P450 StaP: The Catalytic Role of Water Molecules
Yong Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892
Ute Galm et al.
MOLECULAR BIOSYSTEMS (2009)
Biochemical and structural characterization of CYP124: A methyl-branched lipid ω-hydroxylase from Mycobacterium tuberculosis
Jonathan B. Johnston et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis
Pascal Belin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Structural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway
Jason G. Mccoy et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
Sequential Asymmetric Polyketide Heterocyclization Catalyzed by a Single Cytochrome P450 Monooxygenase (AurH)
Martin E. A. Richter et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
The role of the conserved threonine in P450BM3 oxygen activation:: Substrate-determined hydroxylation activity of the Thr268Ala mutant
Max J. Cryle et al.
CHEMBIOCHEM (2008)
Characterization of the peroxidase activity of CYP119, a thermostable P450 from Sulfolobus acidocaldarius
Kersten S. Rabe et al.
CHEMBIOCHEM (2008)
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
Qunfei Zhao et al.
CHEMISTRY & BIOLOGY (2008)
Functional Analysis of MycCI and MycG, Cytochrome P450 Enzymes Involved in Biosynthesis of Mycinamicin Macrolide Antibiotics
Yojiro Anzai et al.
CHEMISTRY & BIOLOGY (2008)
Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp strain PCC 7120
Sean A. Agger et al.
JOURNAL OF BACTERIOLOGY (2008)
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)
Bin Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Characterization of Active Site Structure in CYP121 A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37Rv
Kirsty J. McLean et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450Biol ACP complex
Max J. Cryle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Distinct roles for two CYP226 family cytochromes P450 in abietane diterpenoid catabolism by Burkholderia xenovorans LB400
Daryl J. Smith et al.
JOURNAL OF BACTERIOLOGY (2008)
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula
Aishwarya V. Ramaswamy et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects
Kirsty J. McLean et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)
From genetic diversity to metabolic unity:: Studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes
Bettina Frank et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3
Tatsuya Kitazume et al.
BIOCHEMISTRY (2007)
Cytochrome P450 monooxygenase from Clostridium acetobutylicum:: A new α-fatty acid hydroxylase
Marco Girhard et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC
Katherine S. Ryan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Nonenzymatic oxidative steps accompanying action of the cytochrome p450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin
Annaleise R. Howard-Jones et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
The biosynthesis of teicoplanin-type glycopeptide antibiotics:: Assignment of p450 mono-oxygenases to side chain Cyclizations of glycopeptide a47934
Bianka Hadatsch et al.
CHEMISTRY & BIOLOGY (2007)
Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2
Bin Zhao et al.
BIOCHEMISTRY (2007)
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton
Masatomo Makino et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PksS from Bacillus subtilis is a cytochrome P450 involved in bacillaene metabolism
Jason J. Reddick et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Electron transport pathway for a Streptomyces cytochrome P450 -: Cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2)
Young-Jin Chun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Oxidative phenol coupling reactions catalyzed by OxyB: A cytochrome p450 from the vancomycin producing organism. Implications for vancomycin biosynthesis
Katharina Woithe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC:: application to the analysis of fatty acid oxidation by a P450BM3 mutant
Max J. Cryle et al.
TETRAHEDRON-ASYMMETRY (2007)
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
Rebecca A. Butcher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A type II polyketide synthase from the Gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis
Axel Sandmann et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3)
Max J. Cryle et al.
TETRAHEDRON LETTERS (2007)
Cytochrome P450 systems - biological variations of electron transport chains
Frank Hannemann et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Crystal structure of the Mycobacterium tuberculosis P450CYP121-fluconazole complex reveals new azole drug-P450 binding mode
Harriet E. Seward et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Identification and stereochemical assignment of the β-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway
Kento Koketsu et al.
ORGANIC LETTERS (2006)
Pentalenolactone biosynthesis.: Molecular cloning and assignment of biochemical function to PtII, a cytochrome p450 of Streptomyces avermitilis
Richard Quaderer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid
Annaleise R. Howard-Jones et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Genetic analysis of the balhimycin (vancomycin-type) oxygenase genes
Evi Stegmann et al.
JOURNAL OF BIOTECHNOLOGY (2006)
Cloning and characterization of CYP51 from Mycobacterium avium
Michael P. Pietila et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)
CYP153A6, a soluble P450 oxygenase catalyzing terminal-alkane hydroxylation
Enrico G. Funhoff et al.
JOURNAL OF BACTERIOLOGY (2006)
Biosynthesis of the terpene phenalinolactone in Streptomyces sp Tu6071:: Analysis of the gene cluster and generation of derivatives
C Dürr et al.
CHEMISTRY & BIOLOGY (2006)
Reconstitution of β-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase
K Momoi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases
JB van Beilen et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2006)
Are branched chain fatty acids the natural substrates for P450(BM3)?
Max J. Cryle et al.
CHEMICAL COMMUNICATIONS (2006)
Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?
Max J. Cryle et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD
AR Howard-Jones et al.
BIOCHEMISTRY (2005)
Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus
N Funa et al.
JOURNAL OF BACTERIOLOGY (2005)
The dimeric form of flavocytochrome P450BM3 is catalytically functional as a fatty acid hydroxylase
R Neeli et al.
FEBS LETTERS (2005)
Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups
M Carmody et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108
EM Seco et al.
CHEMISTRY & BIOLOGY (2005)
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine:: sugar donor substrate flexibility of the StaG glycosyltransferase
AP Salas et al.
MOLECULAR MICROBIOLOGY (2005)
NovJ/NovK catalyze benzylic oxidation of a β-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis
M Pacholec et al.
BIOCHEMISTRY (2005)
Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp TP-A0274
H Onaka et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2005)
Calibration of the channel that determines the ω-hydroxylation regiospecificity of cytochrome P4504A1 -: Catalytic oxidation of 12-halododecanoic acids
X He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Theoretical perspective on the structure and mechanism of cytochrome P450 enzymes
S Shaik et al.
CHEMICAL REVIEWS (2005)
Structure and chemistry of cytochrome P450
IG Denisov et al.
CHEMICAL REVIEWS (2005)
Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450
MJ Cryle et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2
B Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin
MV Mendes et al.
BIOCHEMICAL JOURNAL (2005)
The biosynthesis of vancomycin-type glycopeptide antibiotics -: A model for oxidative side-chain cross-linking by oxygenases coupled to the action of peptide synthetases
D Bischoff et al.
CHEMBIOCHEM (2005)
Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations
MJ Cryle et al.
CHEMICAL COMMUNICATIONS (2004)
Carbon-carbon bond cleavage by cytochrome P450BioI (CYP107H1)
MJ Cryle et al.
CHEMICAL COMMUNICATIONS (2004)
Lyngbyatoxin biosynthesis: Sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase
DJ Edwards et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Biosynthesis of chloro-β-hydroxytyrosine, a nonproteinogenic amino acid of the peptidic backbone of glycopeptide antibiotics
O Puk et al.
JOURNAL OF BACTERIOLOGY (2004)
Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome P450 monooxygenase
J He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam
YT Meharenna et al.
BIOCHEMISTRY (2004)
The biosynthetic gene cluster for a monocyclic β-lactam antibiotic, nocardicin A
M Gunsior et al.
CHEMISTRY & BIOLOGY (2004)
EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme
H Ogura et al.
BIOCHEMISTRY (2004)
Characterization of the glycosyltransferase activity of DesVII:: Analysis of and implications for the biosynthesis of macrolide antibiotics
SA Borisova et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
CYP175A1 from Thermus thermophilus HB27, the first β-carotene hydroxylase of the P450 superfamily
F Blasco et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2004)
An oxidative phenol coupling reaction catalyzed by OxyB, a cytochrome p450 from the vancomycin-producing microorganism
K Zerbe et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
A cytochrome P450 involved in the metabolism of abietane diterpenoids by Pseudomonas abietaniphila BKME-9
DJ Smith et al.
JOURNAL OF BACTERIOLOGY (2004)
Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP:: Biophysical properties and interactions with cytochrome p450 BioI
RJ Lawson et al.
BIOCHEMISTRY (2004)
Thermodynamic and biophysical characterization of cytochrome p450 BioI from Bacillus subtilis
RJ Lawson et al.
BIOCHEMISTRY (2004)
Products of cytochrome P450Biol (CYP107H1)-catalyzed oxidation of fatty acids
MJ Cryle et al.
ORGANIC LETTERS (2003)
Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
DC Lamb et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
H Ikeda et al.
NATURE BIOTECHNOLOGY (2003)
Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms
B Shen
CURRENT OPINION IN CHEMICAL BIOLOGY (2003)
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis -: Crystallographic, spectroscopic, and mutational studies
DS Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450
D Leys et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus
AV Puchkaev et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2003)
Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI
AJ Green et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2003)
A novel sterol 14α-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily
CJ Jackson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
CYP119 plus a Sultolobus tokodaii strain 7 ferredoxin and 2-oxoacid:ferredoxin oxidoreductase constitute a high-temperature cytochrome P450 catalytic system
AV Puchkaev et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Cytochrome P450cin (CYP176A), isolation, expression, and characterization
DB Hawkes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
P450camr, a cytochrome P450 catalysing the stereospecific 6-endo-hydroxylation of (1R)-(+)-camphor
G Grogan et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2002)
Oxidizing species in the mechanism of cytochrome P450
PRO de Montellano et al.
NATURAL PRODUCT REPORTS (2002)
Role of the cytochrome P450 NocL in nocardicin a biosynthesis
WL Kelly et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules
J Recktenwald et al.
MICROBIOLOGY-SGM (2002)
Involvement of a cytochrome P450 monooxygenase in thaxtomin a biosynthesis by Streptomyces acidiscabies
FG Healy et al.
JOURNAL OF BACTERIOLOGY (2002)
Enzymatic reaction of hydrogen peroxide-dependent peroxygenase cytochrome P450s: Kinetic deuterium isotope effects and analyses by resonance Raman spectroscopy
I Matsunaga et al.
BIOCHEMISTRY (2002)
Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908:: Function of a haloaenase and a haloperoxidase/perhydrolase
O Puk et al.
CHEMISTRY & BIOLOGY (2002)
Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics
H Chen et al.
CHEMISTRY & BIOLOGY (2002)
Characterization of tdt genes for the degradation of tricyclic diterpenes by Pseudomonas diterpeniphila A19-6a
CA Morgan et al.
CANADIAN JOURNAL OF MICROBIOLOGY (2002)
Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster
HT Chiu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Coumarin formation in novobiocin biosynthesis:: β-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI
HW Chen et al.
CHEMISTRY & BIOLOGY (2001)
Polyketide biosynthesis: a millennium review
J Staunton et al.
NATURAL PRODUCT REPORTS (2001)
Expression, purification, and characterization of biol:: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis
JE Stok et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity
FG Healy et al.
MOLECULAR MICROBIOLOGY (2000)
Expansion of the clavulanic acid gene cluster:: Identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus
RF Li et al.
JOURNAL OF BACTERIOLOGY (2000)
The catalytic pathway of cytochrome P450cam at atomic resolution
I Schlichting et al.
SCIENCE (2000)