Journal
NANOTECHNOLOGY
Volume 29, Issue 13, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aaa7c7
Keywords
biomimetic cell membrane; Fe3O4 nanoparticle; cancer theranostics; immune evasion; tumor targeting
Funding
- National Natural Science Foundation for Outstanding Youth Foundation [61722405]
- National Key R&D Program for Major Research Instruments [81527801]
- National Key RD Program [2016YFC1000700]
- National Natural Science Foundation of China [61474084]
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Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should have long blood circulation times and active cancer targeting. Additionally, they should be harmless and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3O4 NPs). Inherited from the Fe3O4 core and the macrophage membrane shell, the resulting Fe3O4@ MM NPs exhibited good biocompatibility, immune evasion, cancer targeting and light-to-heat conversion capabilities. Due to the favorable in vitro and in vivo properties, biomimetic Fe3O4@ MM NPs were further used for highly effective photothermal therapy of breast cancer in nude mice. Surface modification of synthetic nanomaterials with biomimetic cell membranes exemplifies a novel strategy for designing an ideal nanoplatform for translational medicine.
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