Journal
NANOSCALE
Volume 10, Issue 28, Pages 13432-13442Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr03802c
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Funding
- National Nature Science Foundation of China [51672247]
- '111' Program - Education Ministry of China
- State Administration of Foreign Experts Affairs [B16043]
- Major State Research Program of China [2016YFC1101900]
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Nanoparticles are now commonly used as non-viral gene vectors for RNA interference (RNAi) in cancer therapy but suffer from low targeting efficiency in situ. Meanwhile, localized drug delivery systems do not offer the effective capability for intracellular gene transportation. We describe here the design and synthesis of a localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers. This composite system offers the potential for a LED-induced mild photothermal effect which enhances the phagocytosis of Au NRs carrying siRNA and the subsequent release of siRNA in the cytoplasm. Both phenomena amplify the gene silencing effect and consequently offer the potential for a superior therapeutic outcome.
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