Journal
NANOSCALE
Volume 10, Issue 24, Pages 11430-11440Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr03271h
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Funding
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [51472049, 51741203, 51672044, 51702348, 31701185]
- Shanghai Pujiang Program [16PJ1400200]
- Program for Innovative Research Team in University of Ministry of Education of China [IRT_16R13]
- DHU Distinguished Young Professor Program
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University [LK1620]
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Despite drug delivery systems (DDSs) receiving ever-increasing attention, development of a simple, effective, sensitive and clearable drug delivery and multifunctional theranostic nanoplatform for cancer therapy is still highly desirable and remains a challenge. Herein, using a one-step solvothermal method, hollow acanthosphere-like CuS superstructures assembled from approximate to 10 nm nanoparticles (NPs) were successfully obtained and used as an efficient drug delivery and theranostic platform for photoacoustic (PA) and infrared (IR) thermal imaging-guided cancer combination therapy. The special hollow characteristic of CuS superstructures with mesoporous shells and large cavities grants them high drug loading capacity; they demonstrate near-infrared (NIR)/pH stimuli-sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy both in vitro and in vivo. In particular, our as-fabricated hollow loose CuS superstructures, with easily breakable characteristic, are biodegradable and able to be cleared from the body when their therapy task is completed. This CuS-superstructure-based clearable drug delivery and all-in-one cancer theranostic platform might provide possibilities for improving therapeutic efficacy and minimizing adverse effects.
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