Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 4, Pages 1191-1200Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.02.011
Keywords
Heparin; Magnetic nanoparticles; Vascular cells; Endothelial cells; Neointimal hyperplasia
Funding
- National Science Foundation [NSF CBET CAREER 1254609, DMR 0907167]
- Directorate For Engineering [1254609] Funding Source: National Science Foundation
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0 Restenosis by neointimal hyperplasia is still an ongoing concern in endovascular surgery. Slowing vascular smooth muscle cell (VSMC) proliferation by reversing the phenotype change, would allow vessel healing and re-endotheliazation. To accomplish this, we have developed heparin-coated magnetic nanoparticles for targeted drug therapy of neointimal hyperplasia. Iron oxide nanoparticles were modified with a poly (ethylene oxide) based coating and then further functionalized with heparin. In vitro experiments were conducted to observe changes in phenotype, metabolic activity, and viability of three relevant cell lines including VSMC, endothelial cells and fibroblasts. Inhibition of proliferation of VSMCs was observed with doses as low as 1 mu g/mL Fe of heparin loaded nanoparticle where endothelial cells showed an increase in proliferation in response to treatment. Fibroblasts showed relatively low response. Results suggest proliferation suppression of VSMCs due to phenotype coupled with the increase in endothelial cell proliferation at low doses of heparin coated nanoparticles. (C) 2018 Elsevier Inc. All rights reserved.
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