Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 4, Pages 1227-1236Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.02.004
Keywords
Osteogenic differentiation; Odontogenic differentiation; Dental pulp stem cell; Nanomaterial; Tetrahedral DNA nanostructure
Funding
- National Natural Science Foundation of China [81671031, 81470721]
- Sichuan Province Youth Science and Technology Innovation Team [2014TD0001]
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Dental pulp stem cells (DPSCs) derived from the human dental pulp tissue have multiple differentiation capabilities, such as osteo/odontogenic differentiation. Therefore, DPSCs are deemed as ideal stem cell sources for tissue regeneration. As new nanomaterials based on DNA, tetrahedral DNA nanostructures (TDNs) have tremendous potential for biomedical applications. Here, the authors aimed to explore the part played by TDNs in proliferation and osteo/odontogenic differentiation of DPSCs, and attempted to investigate if these cellular responses could be driven by activating the canonical Notch signaling pathway. Upon exposure to TDNs, proliferation and osteo/odontogenic differentiation of DPSCs were dramatically enhanced, accompanied by up regulation of Notch signaling. In general, our study suggested that TDNs can significantly promote proliferation and osteo/odontogenic differentiation of DPSCs, and this remarkable discovery can be applied in tissue engineering and regenerative medicine to develop a significant and novel method for bone and dental tissue regeneration. (C) 2018 Elsevier Inc. All rights reserved.
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