Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 1, Pages 131-140Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.09.004
Keywords
Superparamagnetic iron oxide nanoparticles; Magnetic resonance imaging; Biodistribution; Chitosan; Fluorescence imaging
Funding
- European Union from the resources of the European Regional Development Fund under the Innovative Economy Program [POIG.01.01.02-00-069/09]
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Bioreactivity of superparamagnetic iron oxide nanoparticles (SPION) coated with thin layers of either cationic or anionic chitosan derivatives and serving as contrast agents in magnetic resonance imaging (MRI) was studied in vivo using BALB/ c mouse model. Synthesized dual-modal fluorescing SPION were tracked in time using both fluorescent imaging and MRI. Although SPION started to be excreted by kidneys relatively shortly after administration they were uptaken by liver enhancing MRI contrast even up to 7 days. Importantly, chitosan-coated SPION caused only mild activation of acute phase response not affecting biochemical parameters of blood. Liver histology indicated the presence of SPION and modest increase in the number of Kupffer cells. The overall results indicated that SPION coated with ultrathin layers of chitosan ionic derivatives can serve as T-2 contrast agents for diagnosis of liver diseases or imaging of other organs assuming the dose is optimized according to the need. (C) 2017 Elsevier Inc. All rights reserved.
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