Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 7, Pages 2283-2294Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.06.011
Keywords
Drug delivery; Anti-angiogenesis; Photothermal therapy; Near-infrared light
Funding
- National Science and Technology Major Project [2017YFA0205400]
- National Natural Science Foundation of China [81373983, 81573377, 81503259]
- Natural Science Foundation [BK20141352, BK20151002]
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Tumor angiogenesis is a key step in the process of tumor development, and antitumor angiogenesis has a profound influence on tumor growth. Herein we report a dual-function drug delivery system comprising a Near-infrared (NIR) dye and an anti-angiogenic drug within liposomes (Lip-IR780-Sunitinib) for enhanced antitumor therapy. The hydrophobic NIR dye IR780 was loaded into the liposome phospholipid bilayer, and the bilayer would be disrupted by laser irradiation so that anti-angiogenic drug sunitinib release would be activated remotely at the tumor site. The released hydrophilic sunitinib could potentially target multiple VEGF receptors on the tumor endothelial cell surface to inhibit angiogenesis. Meanwhile, IR780-loaded liposomes kill the cancer cells by photothermal therapy. Lip-IR780-Sunitinib exhibited enhanced anti-tumor and anti-angiogenic effects in vitro and in vivo. This system facilitates easy and controlled release of cargos to achieve anti-tumor angiogenesis and photothermal therapy. (c) 2018 Elsevier Inc. All rights reserved.
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