Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 3, Pages 1059-1071Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.01.008
Keywords
Trans-resveratrol; Colon cancer; Gold nanoparticles; Technetium-99m
Funding
- Indian Council of Medical Research, New Delhi, India
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When tagged with a suitable radionuclide, the cancer targeting properties of trans-resveratrol could be utilized to locate cancerous sites in the body using radionuclide imaging technique. However, the polyphenol due to its rapid and extensive metabolism exhibits low bioavailability in vivo. The study was designed to enhance the cancer targeting efficacy of radiolabeled resveratrol using nano-based technology. Technetium-(99m) labeled resveratrol loaded gold nanoparticles (Res-AuNP) were synthesized, characterized and evaluated for their cancer targeting efficacy in HT29 colon cancer cells and in animal cancer model. Results of various investigations were compared to corresponding results obtained for Tc-99m-AuNP and Tc-99m-resveratrol. Cancer cell internalization observed for Tc-99m-Res-AuNP was significantly higher than that of Tc-99m-AuNP and Tc-99m-resveratrol. Also, a gradual rise in target to nontarget uptake with time was observed following i.v. administration of Tc-99m-Res-AuNP to colon tumor bearing rats, demonstrating better in vivo targeting of colon adenocarcinoma with Tc-99m-Res-AuNP when compared to Tc-99m-resveratrol. (c) 2018 Elsevier Inc. All rights reserved.
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