Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 5, Pages 1695-1706Publisher
ELSEVIER
DOI: 10.1016/j.nano.2018.04.005
Keywords
Antibacterial nanocomposites; ZnO nanoparticles; Zn acetate; Polycaprolactone; Coaxial electrospinning
Funding
- CONACyT, Mexico City [443935]
- Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City
- Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Mexico City
- Instituto de Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Mexico City
- CONACYT [251279]
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ZnO and Zn acetate nanoparticles were embedded in polycaprolactone coaxial-fibers and uniaxial-fibers matrices to develop potential antibacterial nanocomposite wound dressings (mats). Morphology, composition, wettability, crystallinity and fiber structure of mats were characterized. Antibacterial properties ofmats were tested against E. coli and S. aureus by turbidity and MTT assays. The effect of UVA illumination (prior to bacteria inoculation) on mats' antibacterial activity was also studied. Results showed that a coaxial-fibers design maintained nanoparticles distributed in the outer-shell of fibers and, in general, enhanced the antibacterial effect of the mats, in comparison to conventional uniaxial-fibersmats. Results indicated that mats simultaneously inhibited planktonic and biofilm bacterial growth by, probably, two main antibacterial mechanisms; 1) release of Zn2+ ions (mainly from Zn acetate nanoparticles) and 2) photocatalytic oxidative processes exerted by ZnO nanoparticles. Antibacterial properties of mats were significantly improved by coaxial-fibers design and exposure to UVA-light prior to bacteria inoculation. (C) 2018 Elsevier Inc. All rights reserved.
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