Journal
NANOMEDICINE
Volume 13, Issue 11, Pages 1255-1265Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0029
Keywords
albumin; albumin nanoparticles; intestinal absorption; nanoparticle uptake; oral delivery
Ask authors/readers for more resources
Aim: To explore the potential of albumin nanoparticles for oral drug delivery. Methods: Sub-150 nm human serum albumin nanoparticles were fabricated via a desolvation technique. Nanoparticle cell uptake and epithelial translocation were tested in Caco-2 monolayers, while comparing with albumin solution. Results: Data suggest epithelial transcytosis of albumin, applied in solution form, via neonatal Fc receptor. Cell uptake of albumin nanoparticles demonstrated behaviors indicating a different cell uptake pathway compared with albumin solution. Importantly, application of equivalent concentrations of albumin solution or nanoparticles resulted in higher epithelial transport capacity of the latter, suggesting improvement of intestinal delivery via nanoformulation. Conclusion: This study highlights for the first time that simply fabricated, nontoxic human serum albumin nanoparticles may find application in oral drug delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available