Journal
NANOMEDICINE
Volume 13, Issue 6, Pages 585-594Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0317
Keywords
Alzheimer's disease; blood-brain barrier; nanoparticles
Funding
- ATE-Project - University of Milano-Bicocca [2015-ATE-0510]
- Joint Programme-Neurodegenerative Disease Research (JPND Research) [CUP B42F16000090008]
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Aim: To investigate if and how the ability of liposomes, previously designed for Alzheimer's therapy, to reach the brain changes in aging/pathological conditions with respect to the healthy state. Methods: Biodistribution and pharmacokinetics of liposomes in young or aged healthy mice and in an Alzheimer's mouse model were measured by radiochemical techniques. The expression of brain receptors and structural proteins was evaluated by Western blot. Results: At equal blood levels, the amount and integrity of liposomes in the brain were dramatically lower in Alzheimer's or aged mice, with respect to young animals. These differences are likely attributable to molecular alterations in the brain vasculature. Conclusion: Brain alterations in pathology or aging should be considered in the design of drug delivery systems for brain targeting.
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