Journal
NANOMEDICINE
Volume 13, Issue 13, Pages 1551-1566Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0001
Keywords
liver fibrosis; nanostructured lipid carriers; obesity; Roux-en-Y gastric bypass; self-emulsifying drug delivery system; silibinin
Funding
- Ministry of Science and Technology of Taiwan [NMRPG6F0121]
- Chang Gung Memorial Hospital [CMRPG6D0421]
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Aim: Whether the obesity prevention by chemicals or surgeries in already obese patients is the better choice remains controversial. We aimed to compare the effect of orally silibinin-loaded nanocarriers and Roux-en-Y gastric bypass surgery on hepatic fibrosis in high-fat feeding-induced obese rats. Methodology: The developed nanocarriers included self-emulsifying drug delivery system (SNEDDS) and nanostructured lipid carriers (NLC). Results: A significant decrease in collagen production and lipid droplet formation was observed upon nanosystem and bariatric surgery than the rats treated with silibinin control suspension. Stage 3 fibrosis was present in 33% of the obese rats. This percentage could be minimized to 0% by SNEDDS and NLC. Following oral administration, SNEDDS and NLC resulted in 3.5- and 2.9-fold increase, respectively, in bioavailability compared with the reference suspension. Conclusion: Nanomedicine prevention provided a comparable efficiency to ameliorate liver steatosis as Roux-en-Y gastric bypass due to the improvement of silibinin dissolution and gastrointestinal permeation.
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